3 edition of An investigation of irradiation-induced chromosome aberrations in human leukocytes in culture. found in the catalog.
An investigation of irradiation-induced chromosome aberrations in human leukocytes in culture.
Alexander Graham Bell
Written in English
|Contributions||Toronto, Ont. University.|
|LC Classifications||LE3 T525 MA 1962 B46|
|The Physical Object|
|Pagination||v, 65 leaves.|
|Number of Pages||65|
Aptamers are an emerging class of molecules in cancer therapy. They can be easily synthesized and are considered cost-effective drug candidates. In this book chapter we describe the selection and characterization of DNA aptamers specific to the human epidermal growth factor receptor 2 (ERBB2/HER2), an oncogenic tyrosine kinase. A human hepatic co-culture system for the analysis of cell-cell interactions in vitro 1 2 3 3 1 F. Wewering, J. Florent, D. K. Wissenbach, S. Gebauer, R. Pirow, M. von Bergen2,3,4, S. Kalkhof2, A. Luch1, S. Zellmer1 1 Bundesinstitut für Risikobewertung, Chemikalien- und Produktsicherheit, Berlin, Germany 2 Helmholtz-Centre for.
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Chapter 6 includes chromosome nomenclature based on kinetochore position on chromosomes, karyotyping by aceto-carmine, and Giemsa C- and N-banding methods. Chromosome numbers of some economically important plants are presented in one of the appendices (6-I.). Chapter 7 discusses chromosomal aberrations (structural and numerical chromosome changes). TELOMOLECULAR CORP Securities Registration: Small Business (SB-2/A) EXHIBIT 1. Page. 3 Abstract Human telomerase is a reverse-transcriptase enzyme that synthesizes the multikilobase repeating hexamer telomere sequence (TTAGGG)n at the ends of chromosomes.
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Quantitative relationships between chromosome aberration yields in peripheral blood lymphocytes following in vitro irradiation have been reported by a Cited by: Irradiation-induced chromosome aberrations in normal human leukocytes in culture.
BELL AG, BAKER DG. PMID: [PubMed - indexed for MEDLINE] MeSH Terms. Chromosome Aberrations* Chromosome Disorders* Chromosomes* Humans; Leukocytes* Radiation Genetics*Cited by: An investigation of irradiation-induced chromosome aberrations in human ; leukocytes in short-term culture is described.
In the production of one-hit ; aberrations there appeared to be a linear. The relationship between α-particle dose and chromosome aberration yield was studied in human peripheral blood leukocytes cultured in α-irradiation was produced from thermal neutron capture by boron, according to the nuclear reaction 10 B (n, α) 7 Li.
Blood samples containing 49 μg 10 B per ml were exposed to the thermal neutrons in a reactor at a flux density of 210 7 n/cm 2 by: Chromosomal aberrations detected in the band 1q12 by tandem labelling, in the 17cen-p53 region by FISH using chromosome 17 centromere specific and p53 gene specific probes, and in the whole chromosome 1 by chromosome painting a, in b metaphase wtTK6 cells in untreated and irradiated (3 Gy γ-rays) cultures at 1, 3, 7, 14 and 56 days after Cited by: Start studying effects of radiation on chromosomes.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. chromosome aberrations - when irradiaiton occurs early in interface before DNA synthsis are among the most sensitive of human tissue. death of hematologic depression occurs. With application of POD-FISH it was revealed that AFB1 induced deletions in CNVs in chromosome loci 8p and 15q in human leukocytes culture.
This confirms the idea of Arlt et al. [ 23 ] about the ability of inducers of replicative stress to cause changes in CNVs [ 23 ].Author: Galina Hovhannisyan, Tigran Harutyunyan, Rouben Aroutiounian, Thomas Liehr. In cultured human blood cells, others (Zeni et al., ; Stronati et al., ) reported results that do not support evidence for any DNA damage [SCE, chromosome aberrations (CA), and MN] induced.
Irradiation-induced chromosome aberrations in normal human leukocytes in culture. Canad. Genet. Cytol. 4, – (). E., F ischer, P., S ahit, N. K.: Dose estimation for workers exposed to radon inhalation and an investigation of chromosome aberrations in their peripheral blood lymphocytes.
Health Phys Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.
Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Cell culture, human tissues and animals The human esophageal squamous cancer cell line KYSE was obtained from the Japanese Collection of Research Bioresources (JCRB, Osaka, Japan).
The radioresistant esophageal cancer cell line KYSER was established from KYSE by multiple fractionated irradiation and had been used in our previous Cited by: 7 Nuclear Cytology 1 Allen B. Griffen. Throughout the history of animal nuclear cytology the consensus among investigators has been that the nuclei in the cells of the "germ line" must be the most dependable sources of chromosome counts which will reveal the true diploid chromosome number for the species.
Dose- and time-response curves were combined to assess the potential of the comet assay in radiation biodosimetry. The neutral comet assay was used to detect DNA double-strand breaks in lymphocytes caused by γ-ray irradiation. A clear dose-response relationship with DNA double-strand breaks using the comet assay was found at different times after irradiation (p < ).Cited by: Using cultured human hematopoietic stem and progenitor cells, it was found that 12 C radiation induced chromosome aberrations and cellular apoptosis.
– Gy of 28 Si radiation triggers a significant increase of cellular apoptosis in irradiated mice HSCs at 4 weeks after the exposure, which results in the deficiency of numbers and Author: Huihong Zeng, Mengzhen Yue, Lijian Shao.
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Reactive oxygen species (ROS) is thought to play an important role in cell signaling of apoptosis, necrosis, and proliferation.
Light irradiation increases mitochondrial reactive oxygen species (ROS) production and mediates its intracellular signaling by adjusting the redox potential in tumor : Bo Gao, Debin Zhu.
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Title: Analysis of gamma-ray and neutron-induced chromosome aberrations in CHO-K1 cells using the atomic force microscope Author(s): Meincken M, Smit BS, Sanderson RD, et al.
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Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway.
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